How CORE-ABR grades it
Penicillin non-susceptibility in pneumococcus comes from altered penicillin-binding proteins, which are not panel targets, so beta-lactam grades are conservative. Macrolide activity depends on erm genes.
What the report shows for Streptococcus pneumoniae
- Detected or not detected, with Ct, limit of detection and cycles above LOD — see PCR reporting.
- A short pathogen summary, including colonizer likelihood where it applies.
- A graded column on the antibiogram, and therapy options by scenario on the P.A.C.T. report.
- When not detected, it is still listed among targets tested.
Resistance genes CORE-ABR applies
When detected, each of these genes is applied to Streptococcus pneumoniae only for the agents its mechanism defeats.
ermB / ermCMLSb resistance7 organisms on paneltetB / tetMTetracycline resistance9 organisms on panel
Tagged
Decision support only. The treating clinician decides. Molecular genotype does not replace phenotypic susceptibility testing, culture, or public-health reporting. Absence of a detected resistance gene does not establish susceptibility. Organism targets vary by panel; CORE-ABR is configured to the assay each laboratory runs.