What changes for STI targets
- Treatment follows CDC STI treatment guidelines. For targets such as Chlamydia trachomatis, Neisseria gonorrhoeae and Treponema pallidum, the report points to guideline therapy rather than inventing a grade from genotype.
- No cell wall, no beta-lactam. Mycoplasma and Ureaplasma lack a cell wall, so beta-lactams are inactive by definition.
- Not bacteria at all. Trichomonas vaginalis is a protozoan; HSV and HPV are viruses. The report identifies them without pretending an antibacterial grid applies.
Detecting a non-bacterial cause is itself useful: it is one of the clearest arguments against an unnecessary antibiotic.
Molecular detection does not replace confirmatory testing where guidelines require it, and does not replace public-health reporting obligations.
Pathogens on STI panels
Acinetobacter baumanniiA non-fermenting gram-negative bacillus, notorious in healthcare settings for accumulating resistance.Gram-negative bacteria · UTI · Wound · STICitrobacter freundiiAn Enterobacterales species that carries a chromosomal AmpC beta-lactamase.Gram-negative bacteria · UTI · Wound · STIEnterobacter aerogenes / cloacaeEnterobacterales with chromosomal AmpC. E. aerogenes has been renamed Klebsiella aerogenes; many panels still report the…Gram-negative bacteria · UTI · Wound · STIKlebsiella pneumoniae / oxytocaCommon uropathogens and a leading host of ESBL and KPC carbapenemase genes.Gram-negative bacteria · UTI · Wound · STIPseudomonas aeruginosaA non-fermenting gram-negative bacillus common in chronic wounds and complicated UTI, with a long list of intrinsic resi…Gram-negative bacteria · UTI · Wound · STINeisseria gonorrhoeaeThe cause of gonorrhea, detected on STI and combined UTI/STI panels.Gram-negative bacteria · STIStaphylococcus aureusThe leading cause of skin and soft-tissue infection, and the organism most wound reports are built around.Gram-positive bacteria · UTI · Wound · STIMycoplasma hominis / genitaliumBacteria without a cell wall, found in genitourinary and occasionally wound specimens.Atypical and cell-wall-deficient bacteria · UTI · Wound · STIUreaplasma parvum / urealyticumCell-wall-deficient bacteria frequently present in the lower genitourinary tract, often without disease.Atypical and cell-wall-deficient bacteria · UTI · STIGardnerella vaginalisAn organism associated with bacterial vaginosis, commonly detected on combined UTI/STI panels.Atypical and cell-wall-deficient bacteria · UTI · STITreponema pallidumThe spirochete that causes syphilis.Atypical and cell-wall-deficient bacteria · UTI · STIChlamydia trachomatisAn obligate intracellular bacterium and the most commonly reported bacterial STI in the United States.Atypical and cell-wall-deficient bacteria · STITrichomonas vaginalisA protozoan parasite and the most common curable non-viral STI.Protozoan · UTI · STICandida albicansThe most common Candida species — frequently a colonizer of skin, urine and mucosa, sometimes the cause.Fungus · UTI · Wound · STICandida glabrata / tropicalisNon-albicans Candida species. C. glabrata (now Nakaseomyces glabratus) often shows reduced susceptibility to fluconazole…Fungus · UTI · Wound · STIHerpes simplex virus type 1A common cause of orolabial and, increasingly, genital herpes; detected in ulcerative wound specimens.Virus · Wound · STIHerpes simplex virus type 2The classic cause of recurrent genital herpes.Virus · Wound · STIHPV types 16 and 18High-risk human papillomavirus genotypes associated with cervical and other anogenital cancers.Virus · STI
Resistance genes relevant to STI
Decision support only. The treating clinician decides. Molecular genotype does not replace phenotypic susceptibility testing, culture, or public-health reporting. Absence of a detected resistance gene does not establish susceptibility. Organism targets vary by panel; CORE-ABR is configured to the assay each laboratory runs.